Many cutaneous drug delivery techniques rely on passive diffusion to deliver topical compounds to the skin. When attempting to deliver drugs to thicker lesions, such as skin tumors, modalities that do not rely on diffusion may serve as a better drug‐delivery method. Needle‐free injection was investigated in 24 ex vivo porcine skin samples and one basal cell carcinoma (BCC) tissue sample. A needle‐free injection device with a nozzle size of 200 μm delivered 80 μl compound ink at low (30%), medium (50%), high (65%), and stacked pressures. Depth, width, and depth of maximum width of ink deposition were evaluated on histological slides. Conclusion: with an electronically controlled, pneumatic needle‐free injector, depth and width of a cutaneous deposition can be influenced by pressure and stacking, respectively. The pneumatic needle‐free injection can potentially serve as a viable drug‐delivery technique for cutaneous pathologies where dermal deposition is essential.